Medical news update

- Regulatory Approval vs Guideline Endorsement of Novel BP-Lowering Treatments
This Viewpoint describes the benefits and barriers of conducting cardiovascular disease outcome trials to provide evidence of effectiveness of novel blood pressure (BP)–lowering therapies in […]
- Error in Results
The Original Investigation titled “Polygenic Prediction of Peripheral Artery Disease and Major Adverse Limb Events,” published on May 21, 2025, was corrected to fix 2 incorrect C statistic values […]
- Implantable Cardioverter-Defibrillators in Chagas Cardiomyopathy—Reply
In Reply We thank Dubner and Li et al for their insightful comments on CHAGASICS. Indeed, this is the first randomized clinical trial (RCT) comparing implantable cardioverter-defibrillators (ICDs) […]
- Left Ventricular Noncompaction Cardiomyopathy
This case report describes an echocardiography-based diagnosis of left ventricular noncompaction cardiomyopathy in a male patient in his 40s who presented with sudden-onset dyspnea.
- PCSK9 in Familial Hypercholesterolemia and Beyond
This Viewpoint explores the discovery of PCSK9 inhibitors and discusses their role in the treatment of familial hypercholesterolemia.
- Implantable Cardioverter-Defibrillators in Chagas Cardiomyopathy
To the Editor I read the article regarding the CHAGASICS randomized clinical trial from Martinelli-Filho et al, who evaluated implantable cardioverter-defibrillators (ICDs) against amiodarone in […]
- Finerenone According to Frailty in Heart Failure
This prespecified secondary analysis of the Finerenone Trial to Investigate Efficacy and Safety Superior to Placebo in Patients With Heart Failure (FINEARTS-HF) examines the efficacy and safety of […]
- Cell Adhesion Molecules in Heart Failure
This substudy of the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure (DAPA-HF) randomized clinical trial investigates the association between cell adhesion molecules and adverse […]

- Prognostic models for cardiovascular and kidney outcomes in people with type 2 diabetes: living systematic review and meta-analysis of observational studies
- Prognostic models for cardiovascular and kidney outcomes in people with type 2 diabetes: living systematic review and meta-analysis of observational studies
- Evaluation of comorbidity measures for predicting mortality and revision surgery after elective primary shoulder replacement surgery based on data from the National Joint Registry and Hospital Episode Statistics for England: population based cohort study
- Evaluation of comorbidity measures for predicting mortality and revision surgery after elective primary shoulder replacement surgery based on data from the National Joint Registry and Hospital Episode Statistics for England: population based cohort study
- Cardiorespiratory fitness in adolescence and risk of type 2 diabetes in late adulthood in one million Swedish men: nationwide sibling controlled cohort study
- Cardiorespiratory fitness in adolescence and risk of type 2 diabetes in late adulthood in one million Swedish men: nationwide sibling controlled cohort study
- Association between meeting adult acute asthma best practice tariff standard of care and 30 day and 90 day hospital readmission: nationwide cohort study
- Association between meeting adult acute asthma best practice tariff standard of care and 30 day and 90 day hospital readmission: nationwide cohort study
- Reporting guideline for chatbot health advice studies: the Chatbot Assessment Reporting Tool (CHART) statement
- Reporting guideline for chatbot health advice studies: the Chatbot Assessment Reporting Tool (CHART) statement

- Erratum: Immune profiles in KCNJ5-mutant aldosterone-producing adenomas: pilot characterisation of age and gender differences
No abstract available
- Hypertension doesn’t cause heart failure. Rethinking heart failure with preserved ejection fraction and hypertensive heart disease
No abstract available
- Causal role of the gut microbiota in pulmonary arterial hypertension: insights from Mendelian randomization
No abstract available
- Erratum: Immune microenvironment profiling of primary aldosteronism
No abstract available
- Goal blood pressure in hypertension: the game of numbers. A perspective
No abstract available
- In Memoriam Stevo Julius, MD, ScD
No abstract available
- Aortic characteristic impedance-induced increases in forward wave but not central arterial pulse pressure beyond brachial blood pressure in coronary artery disease
Background: Whether coronary artery disease (CAD) associates with proximal aortic stiffness-induced increases in central arterial forward wave pressures (Pf), but not peak central arterial pulse […]
- Efficacy and safety of sacubitril/valsartan in Afro-descendant patients with resistant hypertension: a randomized controlled trial
Background: Sacubitril/valsartan (Sac-Val) has demonstrated blood pressure (BP)-lowering effects, but its role in resistant hypertension remains unclear. This study evaluated the efficacy and […]

- HYPERTENSION
A Common Link Between Cardiovascular, Kidney, and Metabolic Syndrome (HYPE-CKM)
- ESH 2026
INNOVATIONS IN CARDIOMETABOLIC MANAGEMENT
- ESH MASTERplan for Hypertension Management in CKD – webinars
Did you miss the webinar “ESH MASTERplan for Hypertension Management in CKD”? The recording is now available HERE
- Summer School 2025
Date: 14-19 September 2025 Venue: Särö (Gothenburg), Sweden
- NEW ESH 2024 webinars
Webinar 1: Key Points of the Hypertension Guidelines - The ESH MASTERplan for hypertension Webinar 2: Managing Hypertensive Patients in Clinical Practice – Update on the management of […]
- ESH Webinars 2024
PART 1: Updates on resistant hypertension from novel lifestyle interventions to new drugs and interventional therapies PART 2: Hypertension treatment challenges and options in comorbidities
- ESH 2024
BERLIN MAY 31 - JUNE 3, 2024 www.eshannualmeetings.eu Abstracts are available in Journal of Hypertension
- NEW EUROPEAN GUIDELINES
The final version of the full guidelines is now available on the Journal of Hypertension website.

- Evaluation of Population‐Based Sodium Reduction Strategies in China: Protocol for a Study Using a Combined Quantitative and Qualitative Approach
The Journal of Clinical Hypertension, Volume 27, Issue 8, August 2025.
- Issue Information
The Journal of Clinical Hypertension, Volume 27, Issue 8, August 2025.
- Association of 24‐h Blood Pressure Pattern With Mortality in ICU Patients: A Multicenter Retrospective Study
The Journal of Clinical Hypertension, Volume 27, Issue 8, August 2025.
- Critical Appraisal of Remnant Cholesterol as a Predictor of Cardiovascular Risk in Hypertensive Patients
The Journal of Clinical Hypertension, Volume 27, Issue 8, August 2025.
- Impact Factors for Trajectories of Medication and Healthy Lifestyle Adherence in Young Adults With Hypertension: A Mixed Methods Study
The Journal of Clinical Hypertension, Volume 27, Issue 8, August 2025.
- Letter to the Editor: “Reducing the Risk of Developing Diabetes: The Role of Angiotensin Receptor Blockers and Angiotensin Converting Enzyme Inhibitors in Patients With Hypertension Combined Prediabetes”
The Journal of Clinical Hypertension, Volume 27, Issue 8, August 2025.
- Blood Pressure and Hypertension in Adolescents and Young Adults: Results From a Nationwide Screening Program
The Journal of Clinical Hypertension, Volume 27, Issue 8, August 2025.
- Efficacy, Quality of Life, and Cost‐Effectiveness of Superselective Adrenal Arterial Embolization in Idiopathic Hyperaldosteronism: A Comparative Study
The Journal of Clinical Hypertension, Volume 27, Issue 8, August 2025.

- Critical appraisal of machine learning-based hypertension detection via single-lead electrocardiograms
Journal of Human Hypertension, Published online: 11 August 2025; doi:10.1038/s41371-025-01060-2Critical appraisal of machine learning-based hypertension detection via single-lead electrocardiograms
- Impact of moderate to vigorous physical activity on systemic vascular resistance in Danish adults with recently diagnosed type 2 diabetes: a cross-sectional study
Journal of Human Hypertension, Published online: 07 August 2025; doi:10.1038/s41371-025-01049-xImpact of moderate to vigorous physical activity on systemic vascular resistance in Danish adults with […]
- A systematic review and meta-analysis of digital interventions targeting lifestyle factors in patients with hypertension
Journal of Human Hypertension, Published online: 05 August 2025; doi:10.1038/s41371-025-01051-3A systematic review and meta-analysis of digital interventions targeting lifestyle factors in patients […]
- Associations between cardiovascular health metrics in life’s essential 8 and incident hypertension: The LIFE Study
Journal of Human Hypertension, Published online: 05 August 2025; doi:10.1038/s41371-025-01059-9Associations between cardiovascular health metrics in life’s essential 8 and incident hypertension: […]
- Cerebrovascular reactivity impairment in resistant hypertension
Journal of Human Hypertension, Published online: 02 August 2025; doi:10.1038/s41371-025-01058-wCerebrovascular reactivity impairment in resistant hypertension
- Association between bullous pemphigoid and hypertension: a systematic review and meta-analysis of observational studies
Journal of Human Hypertension, Published online: 29 July 2025; doi:10.1038/s41371-025-01056-yAssociation between bullous pemphigoid and hypertension: a systematic review and meta-analysis of […]
- Exploration of potential therapeutic target genes for preeclampsia through genetic analysis
Journal of Human Hypertension, Published online: 25 July 2025; doi:10.1038/s41371-025-01054-0Exploration of potential therapeutic target genes for preeclampsia through genetic analysis
- Vagal dysfuction in resistant hypertension: no longer the “cinderella” of the autonomic cardiovascular profile
Journal of Human Hypertension, Published online: 25 July 2025; doi:10.1038/s41371-025-01053-1Vagal dysfuction in resistant hypertension: no longer the “cinderella” of the autonomic cardiovascular […]
- How Well Do Adults Understand Aspirin's Harms and Benefits?
A new poll shows that many older adults overestimate benefits — and underestimate harm — of aspirin for primary prevention.
- Selecting an Aspirin-Free Strategy for Patients with High Bleeding Risk Undergoing PCI: Does ACS Indication Matter?
Based on trial data, having a PCI indication of acute coronary syndrome (vs. non-ACS) does not change major bleeding risk but may increase cardiovascular events.
- Could Sodium Supplementation Benefit Patients with Acute Decompensated Heart Failure?
A meta-analysis suggests that sodium supplementation, along with loop diuretics, confers more clinical benefit than loop diuretics alone; however, questions remain, and the practice likely should be […]
- Optimal Management of NSTEMI in Older Adults: A Meta-Analysis
An invasive management strategy did not improve survival compared with a conservative approach but did lower morbidity risk.
- Which Cardiovascular Risk Calculator Is Best in Older Adults?
PREVENT proved much more accurate than the older calculator in older adults.
- A New Indication for Finerenone, a Mineralocorticoid-Receptor Antagonist
The FDA has approved this drug for treating patients with heart failure and preserved or mildly reduced ejection fraction.
- Should Patients Take Once-Daily Antihypertensive Drugs in the Morning or the Evening?
More evidence shows that when these medications are taken doesn't alter benefits or harms.
- Exercise as Medicine for Preventing Colon Cancer Recurrence
Structured exercise significantly reduces recurrence risk and improves survival for stage II and III colon cancer.